Dengue Virus Test

Short Description:

CAT # PRODUCT DESCRIPTION SPECIMEN CUT-OFF SENSITIVITY SPECIFICITY ACCURACY FORMAT KIT SIZE RID01C Dengue Ns1 Ag Ns1 Antigen to Dengue virus Test WB/S/P N/A 95.70% 98.3%% 97.70% Cassette 25T RID02C Dengue IgG/IgM IgG and IgM antibodies to Dengue virus 3-line Test WB/S/P N/A 95.80% 99.00% 99.30% Cassette 25T RID03C Dengue Ns1+IgG/IgM Ns1 Antigen, IgG and IgM antibodies to Dengue virus Duo Test WB/S/P N/A IgG/IgM:95.8%  Ns1:95.7% IgG...


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Product Tags

Product Parameters

CAT # PRODUCT DESCRIPTION SPECIMEN CUT-OFF SENSITIVITY SPECIFICITY ACCURACY FORMAT KIT SIZE

RID01C

Dengue Ns1 Ag

Ns1 Antigen to Dengue virus Test

WB/S/P

N/A

95.70%

98.3%%

97.70%

Cassette

25T

RID02C

Dengue IgG/IgM

IgG and IgM antibodies to Dengue virus 3-line Test

WB/S/P

N/A

95.80%

99.00%

99.30%

Cassette

25T

RID03C

Dengue Ns1+IgG/IgM

Ns1 Antigen, IgG and IgM antibodies to Dengue virus Duo Test

WB/S/P

N/A

IgG/IgM:95.8%  Ns1:95.7%

IgG/IgM:99.0%  Ns1:98.3%

IgG/IgM:99.3%  Ns1:97.7%

Cassette

25T

RID04C

Dengue Ns1+IgG/IgM individual

Ns1 Antigen, IgG and IgM antibodies to Dengue virus Duo Test  with individual buffer, safety lancet, alcohol pad etc.

WB/S/P

N/A

IgG/IgM:95.8%  Ns1:95.7%

IgG/IgM:99.0%  Ns1:98.3%

IgG/IgM:99.3%  Ns1:97.7%

Cassette

25T

Summary

Dengue viruses, transmitted by the mosquito, Aedes aegypti and Aedes albopictus mosquitoes, are widely distributed throughout the tropical and subtropical areas of the world. There are four known distinct serotypes (dengue virus 1,2,3 and 4). In children, infection is often subclinical or causes a self-limited febrile disease. However, if the patient is infected second times with a different serotype, a more severe disease, dengue hemorrhagic fever or dengue shock syndrome, is more likely to occur. Dengue is considered to be the most important arthropod-borne viral disease due to the human morbidity and mortality it causes.

Traditionally, the serological diagnosis of an acute dengue virus infection has relied on showing a 4-fold or greater rise in anti-dengue virus antibody between paired acute- and convalescent-phase sera from a patient. The haemagglutination-inhibition test has been the most commonly used serological assay for dengue diagnosis.

Rapid and reliable tests for primary and secondary infections of dengue are essential for patient management. Primary Dengue infection is associated with mild to high fever, headache, muscle pain and skin rash. Immune response includes IgM antibodies produced by 5th day of symptoms and persist for 30—60 days. IgGs appear the 14th day and persist for life. Secondary infections often result in high fever and in many cases with haemorrhagic events and circulatory failure. Secondary infections show that IgGs rise within 1-2 days after the onset of symptoms and induce IgM response after 20 days of infection.

NS1 (non-structural protein is a highly conserved glycoprotein that is essential for the viability of dengue virus (DV) and is produced both in membrane-associated and secretory forms by the virus. Enzyme-linked immunosorbent assays (ELISA) directed against NS1 antigen (NS1 Ag) have demonstrated its presence at high concentrations in the sera of dengue virus (DV) infected patients during the early clinical phase of the disease.

EUGENE® Dengue Ns1+IgG/IgM Rapid Test detects secretory NS1 protein and simultaneously detects and differentiates IgG and IgM antibodies to dengue virus in human whole blood serum or plasma. It represents a new approach to the diagnosis of acute dengue virus (DV) infection.


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