Antibodies to Hepatits C Virus Test

Short Description:

CAT # PRODUCT DESCRIPTION SPECIMEN CUT-OFF SENSITIVITY SPECIFICITY ACCURACY FORMAT KIT SIZE RI301S Anti-HCV Antibodies to Hepatits C Virus Test Serum/Plasma N/A 98.10% 98.90% 98.90% Strip 50T RI301C Anti-HCV Antibodies to Hepatits C Virus Test WB/S/P N/A 98.10% 98.90% 98.90% Cassette 25T RI302C Anti-HCV from BNIBT Antibodies to Hepatits C Virus Test WB/S/P N/A 99.69% 99.85% 99.80% Cassette 25T Hepatitis C is an infectiou...

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Product Parameters

CAT #	PRODUCT	DESCRIPTION	SPECIMEN	CUT-OFF	SENSITIVITY	SPECIFICITY	ACCURACY	FORMAT	KIT SIZE
RI301S	Anti-HCV	Antibodies to Hepatits C Virus Test	Serum/Plasma	N/A	98.10%	98.90%	98.90%	Strip	50T
RI301C	Anti-HCV	Antibodies to Hepatits C Virus Test	WB/S/P	N/A	98.10%	98.90%	98.90%	Cassette	25T
RI302C	Anti-HCV from BNIBT	Antibodies to Hepatits C Virus Test	WB/S/P	N/A	99.69%	99.85%	99.80%	Cassette	25T

Summary

Hepatitis C is an infectious disease primarily affecting the liver, caused by the hepatitis C virus (HCV).1 The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years. In some cases, those with cirrhosis will go on to develop liver failure or other complications, including liver cancer or life-threatening esophageal varices and gastric varices. 1 Hepatitis C virus is a single stranded RNA virus with some structural relations to the flavivirus family. Nucleic acid sequences of HCV cDNA clones provided the basis for the construction of recombinant peptides representing putative Hepatitis C virus proteins.2 In recent study, proteins of core, NS3, NS4, and NS5 were found to be highly immunogenic among 11 types of Hepatitis C virus proteins.3-5 Compared to the earlier generations of HCV test using single or double recombinant antigens, the EUGENE® Anti-HCV rapid test uses multiple recombinant proteins to detect antibodies, so as to obtain an improved sensitivity and specificity.

Principle

The EUGENE® Anti-HCV rapid test is a lateral flow, immunochromatographic assay, screening whole blood, serum or plasma using recombinant HCV proteins. Recombinant antigens of HCV labeled by gold conjugates are used in test band as capture materials, and anti-rabbit HCV antibody is used in the control band. When a sample is added into the sample well of the device, it migrates through the membrane strip. If the antibodies to HCV present in the specimen, a complex of antibody-gold conjugated recombinant antigens will be formed, which is then captured by antigen immobilized in the Test Zone of the membrane, producing a visible pink color band of immunocomplex conjugate on the membrane. The color intensity will depend on the concentration of the anti-HCV present in the sample. Absence of the Test band suggests a negative result. The test contains an internal control (C band) which should exhibit a pink colored band of the immunocomplex conjugate regardless of color development on the Test band. Otherwise, the test result is invalid and the specimen must be retested with another device.